objective(s) in this study, effects of chronic administration of oral natural honey against ischemia/reperfusion (i/r)-  induced cardiac arrhythmias were investigated in isolated rat heart. materials and methods male wistar rats were divided into four groups (n= 10-14 rats in each group) and fed with natural honey (1%, 2% and 4% dissolved in the drinking water) for 45 days except for the contro...

myocardial infarction is a common presentation of coronary artery disease and the leading cause of death worldwide. the present study was investigated potential resistance to ischemia-reperfusion (i/r) injuries following administration of methanolic (meoh) extract of scrophularia frigida (s. frigida) in isolated rat heart. male wistar rat hearts (n= 8-10) were isolated and allowed to equilibrat...

objective(s): electrical inhomogeneity between ischemic and non ischemic myocardium is the basis of arrhythmia which occurs following coronary artery occlusion. the leakage of potassium from the ischemic region to the non ischemic region is very effective in the generation of these arrhythmias. the aim of this study is to research the effect of atp-dependent potassium (katp) channel blocker (gl...

introduction: inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. the aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ace) inhibitor, ramiprilat and angiotensin type 1 (at1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat model...

objective(s) dracocephalum moldavica (d. moldavica) have been traditionally used as a cardiotonic agent in the folk medicine of some regions of iran. in the present study, effects of total extract of d. moldavica on ischemia/reperfusion induced arrhythmias and infarct size investigated in isolated rat heart. materials and methods the isolated hearts were mounted on a langendorff apparatus then ...

background and objective : sleep deprivation (sd) is caused by a host of reasons and has numerous consequences on cardiac system. in this study, we aimed to assess the preconditioning effects of acute sd on ischemia (is)-induced ventricular arrhythmias in isolated rat hearts. materials and methods : male wistar rats randomly were placed into the four groups: is-group, acute sd group, control gr...

in the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. the hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. in the control group, the hearts were perfused by normal drug free krebs-henseleit (k/h) solution t...

objective(s) this study aimed to examine whether acetyl-l-carnitine (alc) was able to reduce cardiac arrhythmias and infarct size in the ischemic-reperfused isolated rat heart. materials and methods the isolated hearts were mounted on a langendorff apparatus then perfused by a modified krebs-henseleit solution during 30 min regional ischemia and 120 min reperfusion (control) or by enriched kreb...

objective(s):this study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. materials and methods: male wistar rats were anesthetized by thiopental sodium (50 mg/kg, ip) followed by iv injection of heparin (250 iu). remote ischemic preconditioning (ripc) was induce...

background: this study was conducted to reveal that whether i.v. injection of oleuropein, the most potent polyphenolic antioxidant in olive leaf, has any effect on the magnitude of reperfusion arrhythmia in anesthetized rats or not. methods: eighty male wistar rats were divided into 8 groups of 10 each: groups 1 and 5 were assigned as the prophylactic and treatment control groups, groups 2 and ...